Conjugated linoleic acid (CLA) is the fatty acid group of compounds with conjugated double bonds in the intermole-
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چکیده
compounds with conjugated double bonds in the intermolecule of linoleic acid. CLA was discovered by Kepler et al. in 1966. It has been described as an anticarcinogenic agent in grilled ground beef. Recently, CLA has gained explosive popularity with athletes and body builders in the U.S.A. based on reports of body fat reduction and lean body mass enhancement attributed to it. CLA exerts diverse physiological actions against carcinogenesis, arteriosclerosis, diabetes, and cardiovascular disease. The immune system is also affected by CLA. CLA modulates certain aspects of immune defense, including increased lymphocyte blastogenesis, macrophage phagocytes, and lymphocyte proliferation. On the other hand, in the superfluous immune response, CLA increases the production of IgA and IgG, promoting the allergic response through their reduction, while reducing IgE by promoting the allergic response through a superfluous increase in lymphocytes. CLA was also found to stimulate moderate production of arachidonic acid and arachidonate-derived eicosanoid, including COX-2 activity or expression. CLA inhibits the release of cytokines, histamine, and prostaglandin-E2 (PGE2) 16) from immune cells. These reports led us to expect that CLA would inhibit the anaphylaxis (type I hypersensitivity reaction) and allergic pruritus by affecting chemical mediators. This paper describes the inhibitory effects of CLA against anaphylaxis using a blood pressure (BP) or blood flow (BF) monitoring assay system and against allergic pruritus using a scratching (itch-associated response) measuring assay system.
منابع مشابه
Conjugated Linoleic Acid Production and Optimization Via Catalytic Reaction Method Using Safflower Oil
Conjugated linoleic acid (CLA) is one of the most physiological active fatty acids due to its positive effect on prevention of diseases such as obesity, hyperlipidemia, atherosclerosis and cancer. The aim of this study was to optimize the production of conjugated linoleic acid (CLA)% in alkali isomerization of safflower oil including 71% linoleic acid (LA) using response surface methodology...
متن کاملLipase Catalyzed Incorporation of Conjugated Linoleic Acid by Transesterification into Sunflower Oil Applying Immobilized Lipase (Lipozyme Thermomyces lanuginosus and Rhizomucor mehei)
Conjugated Linoleic Acid (CLA), Glycerol (G) and sunflower oil blends with varying concentration were subjected to enzymatic esterification using a 1, 3- specific immobilized lipase. CLA was used as acyl due to its purported health benefits. The transesterified lipids were evaluated for free fatty acids (FFA) and composition of fatty acids by gas chromatography. Lipozyme RM IM is preferred for ...
متن کاملTrans-10, cis-12 Conjugated Linoleic Acid
Conjugated linoleic acids (CLA) are a group of linoleic acid isomers having double bonds in conjugated position, i. e. the double bonds are separated by one single bond. Two of the isomers: cis-9, trans-11 (c9, t11) and trans-10, cis-12 (t10, c12) CLA, have been shown to have biologically interesting properties. The c9, t11 CLA has been reported to have anticancer, antidiabetic and anti-inflamm...
متن کاملThe Metabolic Effects of Conjugated Linoleic Acids (CLA) in Chickens: A Review
Conjugated linoleic acids (CLA) are natural constituents of meat and dairy products from ruminants, originating from bacterial biohydrogenation in the rumen. CLA supplementation increases the health benefits of animal-derived foods. There are inconsistent reports of the effects of dietary CLA on chicken’s performance; however, the majority of previous reports cite anti-lipogenic effects of CLA....
متن کاملConjugated Linoleic Acid
Conjugated linoleic acid, better known as CLA, is a fatty acid derived from the required nutrient, linoleic acid. The major structural difference between linoleic acid (an 18 carbon, polyunsaturated fatty acid) and CLA, is that linoleic acid has double bonds at carbons 9 and 12 in a cis configuration (methylene interrupted), while CLA has numerous isomers without methylene interrupted conjugate...
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تاریخ انتشار 2002